The Yomiuri Shimbun has a reputation for particular strength in the field of medicine. This goes beyond our coverage of the subject in newspapers and includes the Yomiuri Group's Shoriki Kosei-kai (welfare foundation), which offers support to Japanese patients and their families. It is a public foundation that takes its name from Matsutaro Shoriki (1885-1969), the former head of The Yomiuri Shimbun. In its earlier incarnation, the foundation's activities focused on donating wheelchairs to welfare facilities.Currently, the foundation offers grants to cancer organizations and patients so they can utilize medical facilities and improve their quality of life. It also hosts the Cancer Treatment Forum and holds hospital concerts for people receiving cancer treatment.

The social welfare body of the Yomiuri Shimbun Group, the Yomiuri Light and Humanity Association, supports the disabled and disaster victims. The association collected \2.9 billion in donations following the March 2011 Great East Japan Earthquake to support victims of that disaster. Other projects include grants to organizations that employ the disabled, allowing them to receive better wages, and the offering of corneal transplants for patients whose sight can only be restored through that procedure. The association also operates an elderly care facility in Kawasaki, Kanazawa Prefecture.

The Yomikaki-no-mori nursery for children under school age is located in the Yomiuri Shimbun building in Otemachi, Tokyo. It is available both to employees of the Yomiuri Shimbun Group and employees from partnering nearby companies. Founded in 2014, this was the first nursery in Japan to be established within the offices of a newspaper company.